Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral
heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to molecularly …

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving
transcriptional heterogeneity. However, its application to studying cancerous tissues is currently …

Proper regulation of the balance between hematopoietic stem cell (HSC) proliferation, self-renewal,
and differentiation is necessary to maintain hematopoiesis throughout life. The Wnt …

Human lymphopoiesis is a dynamic lifelong process that starts in utero 6 weeks postconception.
Although fetal B-lymphopoiesis remains poorly defined, it is key to understanding …

The hematopoietic system is well established as a paradigm for the study of cellular hierarchies,
their disruption in disease and therapeutic use in regenerative medicine. Traditional …

The ability of dendritic cells (DCs) to stimulate and regulate T cells is critical to effective anti-tumor
immunity. Therefore, it is important to fully recognize any inherent factors which may …

Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually
caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, …

Samples are negative for NPM1 and FLT3-ITD except where noted as positive. Sample ID
numbers correspond to those values shown in Figure 1. Characteristics of samples from …

The production of new blood cells relies on a hierarchical network of hematopoietic stem
and progenitor cells (HSPCs). To maintain lifelong hematopoiesis, HSPCs must be protected …

Somatic mutations in acute myeloid leukemia are acquired sequentially and hierarchically.
First, pre-leukemic mutations, such as t (8; 21) that encodes AML1-ETO, are acquired within …