Apicomplexan parasites exhibit tremendous diversity in much of their fundamental cell biology,
but study of these organisms using light microscopy is often hindered by their small size. …

The malaria parasite Plasmodium falciparum undergoes closed mitosis, which occurs within
an intact nuclear envelope, and differs significantly from its human host. Mitosis is …

Apicomplexan parasites, such as human malaria parasites, have complex lifecycles encompassing
multiple and diverse environmental niches. Invading, replicating, and escaping from …

Apicomplexan parasites comprise significant pathogens of humans, livestock and wildlife, but
also represent a diverse group of eukaryotes with interesting and unique cell biology. The …

During its intraerythrocytic development, the malaria parasite Plasmodium falciparum
exposes variant surface antigens (VSAs) on infected erythrocytes to establish and maintain an …

The disease-causing blood-stage of the Plasmodium falciparum lifecycle begins with invasion
of human erythrocytes by merozoites. Many vaccine candidates with key roles in binding …

Proteins of the lipocalin family are known to bind small hydrophobic ligands and are
involved in various physiological processes ranging from lipid transport to oxidative stress …

Background Resistance to front-line antimalarials (artemisinin combination therapies) is
spreading, and development of new drug treatment strategies to rapidly kill Plasmodium spp. …

Apicomplexan parasites contain rhoptries, which are specialized secretory organelles that
coordinate host cell invasion. During the process of invasion, rhoptries secrete their contents …

Membrane transport proteins perform crucial roles in cell physiology. The obligate intracellular
parasite Plasmodium falciparum , an agent of human malaria, relies on membrane …