Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …

Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …

Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …

Objective: Individuals at high risk for schizophrenia may benefit from early intervention, but
few validated risk predictors are available. Genetic profiling is one approach to risk …

Understanding population health disparities is an essential component of equitable precision
health efforts. Epidemiology research often relies on definitions of race and ethnicity, but …

Quantitative changes in leptin concentration lead to alterations in food intake and body weight,
but the regulatory mechanisms that control leptin gene expression are poorly understood. …

Background Melanocortin 4 receptor (MC4R) deficiency, caused by mutations in MC4R, is
the most common cause of monogenic forms of obesity. However, these mutations have often …

Background Pathogenic variants in BRCA1 and BRCA2 (BRCA1/2) lead to increased risk of
breast, ovarian, and other cancers, but most variant-positive individuals in the general …