Developing technologies for efficient and scalable disruption of gene expression will
provide powerful tools for studying gene function, developmental pathways, and disease …

Tissue engineering approaches have the potential to increase the physiologic relevance of
human iPS-derived cells, such as cardiomyocytes (iPS-CM). However, forming Engineered …

Molecular chaperones regulate quality control in the human proteome, pathways that have
been implicated in many diseases, including heart failure. Mutations in the BAG3 gene, which …

Mutations in the cardiac splicing factor RBM20 lead to malignant dilated cardiomyopathy (DCM).
To understand the mechanism of RBM20-associated DCM, we engineered isogenic …

Purpose The timely delivery of health care is an important quality indicator that has been
shown to correlate with outcomes for cancer patients. We present our single-institution …

Importance The role of surveillance imaging after treatment for head and neck cancer is
controversial and evidence to support decision-making is limited. Objective To determine the …

Background The emergence of drug-resistant Neisseria gonorrhoeae has prompted the
development of rapid molecular assays designed to determine antimicrobial susceptibility. One …

Purpose To analyze practice patterns focusing on variations in the timing of chemotherapy
relative to radiation in patients treated with concurrent chemoradiation for head and neck …

Multiple genetic association studies have correlated a common allelic block linked to the
BAG3 gene with a decreased incidence of heart failure, but the molecular mechanism remains …

On postoperative Day 15, she presented emergently with new-onset nausea, vomiting, and
abdominal cramping. On physical examination, she was tachycardic (heart rate of 104 beats/…