[HTML][HTML] Spinal muscular atrophy diagnosis and carrier screening from genome sequencing data

X Chen, A Sanchis-Juan, CE French, AJ Connell… - Genetics in …, 2020 - nature.com
Purpose Spinal muscular atrophy (SMA), caused by loss of the SMN1 gene, is a leading
cause of early childhood death. Due to the near identical sequences of SMN1 and SMN2, …

[HTML][HTML] Sunbeam: an extensible pipeline for analyzing metagenomic sequencing experiments

EL Clarke, LJ Taylor, C Zhao, A Connell, JJ Lee, B Fett… - Microbiome, 2019 - Springer
Background Analysis of mixed microbial communities using metagenomic sequencing
experiments requires multiple preprocessing and analytical steps to interpret the microbial and …

Angle of arrival estimation using decawave DW1000 integrated circuits

I Dotlic, A Connell, H Ma, J Clancy… - 2017 14th Workshop …, 2017 - ieeexplore.ieee.org
The paper describes principles of angle of arrival estimation using an anchor and a tag
which are built around Decawave's DW1000 impulse radio ultra-wideband IC. Typical …

[HTML][HTML] Lifestyle and the presence of helminths is associated with gut microbiome composition in Cameroonians

MA Rubel, A Abbas, LJ Taylor, A Connell, C Tanes… - Genome biology, 2020 - Springer
Background African populations provide a unique opportunity to interrogate host-microbe co-evolution
and its impact on adaptive phenotypes due to their genomic, phenotypic, and …

A place-based system? Regional policy levers and the UK's productivity challenge

H Tilley, J Newman, A Connell, C Hoole… - Regional …, 2023 - Taylor & Francis
National governments are increasingly focusing on ‘place’ in attempts to tackle economic
challenges. This puts pressure on regions to deliver productivity improvements. Drawing from …

Engineered coatings for titanium implants to present ultralow doses of BMP-7

…, V Moulisová, A Leal-Egaña, A Connell… - ACS biomaterials …, 2018 - ACS Publications
The ongoing research to improve the clinical outcome of titanium implants has resulted in the
implemetation of multiple approches to deliver osteogenic growth factors accelerating and …

[HTML][HTML] Evaluation of the orally bioavailable 4-phenylbutyrate-tethered trichostatin A analogue AR42 in models of spinal muscular atrophy

CJ Lumpkin, AW Harris, AJ Connell, RW Kirk… - Scientific Reports, 2023 - nature.com
Proximal spinal muscular atrophy (SMA) is a leading genetic cause for infant death in the
world and results from the selective loss of motor neurons in the spinal cord. SMA is a …

Ranging methods utilizing carrier frequency offset estimation

I Dotlic, A Connell, M McLaughlin - 2018 15th Workshop on …, 2018 - ieeexplore.ieee.org
Precise digital estimation of Carrier Frequency Offset (CFO) between transmitter and
receiver is an inherent part of the frame reception in some coherent radio architectures, eg, …

[HTML][HTML] Ruxolitinib cream has dual efficacy on pruritus and inflammation in experimental dermatitis

MD Scuron, BL Fay, AJ Connell, MT Peel… - Frontiers in …, 2021 - frontiersin.org
The goal of this study was to elucidate the anti-pruritic and anti-inflammatory efficacy of
ruxolitinib cream in experimentally-induced dermatitis. Atopic dermatitis (AD), the most common …

Making sense of knowledge-brokering organisations: boundary organisations or policy entrepreneurs?

E MacKillop, A Connell, J Downe… - Science and Public …, 2023 - academic.oup.com
Abstract Knowledge-brokering organisations (KBOs) have multiplied in the evidence–policy
landscape worldwide, changing how decision-makers are accessing evidence. Yet, we still …