Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results
primarily from the death of dopaminergic neurons in the substantia nigra. Although the …

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) cause late-onset Parkinson's
disease (PD) with a clinical appearance indistinguishable from idiopathic PD. Initial studies …

Mutations in the leucine-rich repeat kinase 2 gene ( LRRK2 ) cause late-onset Parkinson's
disease indistinguishable from idiopathic disease. The mechanisms whereby missense …

Objective The PARK8 gene responsible for late‐onset autosomal dominant Parkinson's
disease encodes a large novel protein of unknown biological function termed leucine‐rich …

Parkinson's disease (PD) is a disorder of movement, cognition, and emotion, and it is
characterized pathologically by neuronal degeneration with Lewy bodies, which are cytoplasmic …

Recent studies of genomic variation associated with autism have suggested the existence
of extreme heterogeneity. Large-scale transcriptomics should complement these results to …

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's
disease (PD), and common genetic variation in LRRK2 modifies susceptibility to Crohn's …

Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's
disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo …

Aggregates of α-synuclein (α-syn) accumulate in neurons in Parkinson's disease and other
synucleinopathies. These inclusions predominantly localize to axons even in the early stages …

Human genetic studies implicate LRRK2 and RAB7L1 in susceptibility to Parkinson disease
(PD). These two genes function in the same pathway, as knockout of Rab7L1 results in …