Cancer metastasis requires that primary tumour cells evolve the capacity to intravasate into
the lymphatic system or vasculature, and extravasate into and colonize secondary sites 1 . …

The partitioning of genetic material between the nucleus and cytoplasmic (mitochondrial
and plastid) genomes within eukaryotic cells necessitates coordinated integration between …

Mitochondria, a nearly ubiquitous feature of eukaryotes, are derived from an ancient
symbiosis. Despite billions of years of cooperative coevolution — in what is arguably the most …

Partitiviruses are segmented, multipartite double-stranded RNA (dsRNA) viruses that until
recently were only known to infect fungi, plants, and protozoans. Metagenomic surveys have …

Eukaryotic cells represent an intricate collaboration between multiple genomes, even down
to the level of multi‐subunit complexes in mitochondria and plastids. One such complex in …

Nuclear and plastid (chloroplast) genomes experience different mutation rates, levels of
selection, and transmission modes, yet key cellular functions depend on their coordinated …

There is remarkable variation in the rate at which genetic incompatibilities in molecular
interactions accumulate. In some cases, minor changes—even single-nucleotide substitutions—…

The pressure to survive ever-changing pathogen exposure explains the frequent observation
that immune genes are among the fastest evolving in the genomes of many taxa, but an …

The angiosperm genus Silene is a model system for several traits of ecological and evolutionary
significance in plants, including breeding system and sex chromosome evolution, host-…

The chloroplast chaperone CLPC1 unfolds and delivers substrates to the stromal CLPPRT
protease complex for degradation. We previously used an in vivo trapping approach to …