Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to
vision impairment. Development of cell therapy requires a better understanding of the signals …

Human embryonic stem cells (hESCs) have great potential for use in research and
regenerative medicine, but very little is known about the factors that maintain these cells in the …

Studies of rodent models of Alzheimer’s disease (AD) and of human tissues suggest that the
retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may …

Sphingosine‐1‐phosphate (S1P) is a potent lysophospholipid mediator mostly released by
activated platelets. It is involved in several functions in peripheral tissues, but its effects in the …

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) regulate a diverse range
of mammalian cell processes, largely through engaging multiple G protein-coupled receptors …

Glaucoma, the worldwide leading cause of irreversible blindness, is characterized by
progressive degeneration of the optic nerve and loss of retinal ganglion cells. Research into …

Purpose: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated
protein (Cas) has recently been adapted to enable efficient editing of the …

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in the …

Friedreich ataxia (FRDA) is an autosomal recessive disorder characterised by neurodegeneration
and cardiomyopathy. It is caused by a trinucleotide (GAA) repeat expansion in the first …

There are currently no treatments for geographic atrophy, the advanced form of age-related
macular degeneration. Hence, innovative studies are needed to model this condition and …