BRCA1 Suppresses Epithelial-to-Mesenchymal Transition and Stem Cell Dedifferentiation during Mammary and Tumor Development
BRCA1 mutation carriers are predisposed to developing basal-like breast cancers with high
metastasis and poor prognosis. Yet, how BRCA1 suppresses formation of basal-like breast …
metastasis and poor prognosis. Yet, how BRCA1 suppresses formation of basal-like breast …
Effects of pairing on color change and central gene expression in lined seahorses
Social monogamy is a reproductive strategy characterized by pair living and defense of a
common territory. Pair bonding, sometimes displayed by monogamous species, is an affective …
common territory. Pair bonding, sometimes displayed by monogamous species, is an affective …
[HTML][HTML] Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression
C Wang, F Bai, L Zhang, A Scott, E Li, XH Pei - Breast Cancer Research, 2018 - Springer
Background Estrogen promotes breast cancer development and progression mainly through
estrogen receptor (ER). However, blockage of estrogen production or action prevents …
estrogen receptor (ER). However, blockage of estrogen production or action prevents …
[HTML][HTML] Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence
Cryptococcal disease is estimated to affect nearly a quarter of a million people annually.
Environmental isolates of Cryptococcus deneoformans, which make up 15 to 30% of clinical …
Environmental isolates of Cryptococcus deneoformans, which make up 15 to 30% of clinical …
[HTML][HTML] BMP signaling modulates hedgehog-induced secondary heart field proliferation
LA Dyer, FA Makadia, A Scott, K Pegram… - Developmental …, 2010 - Elsevier
Sonic hedgehog signaling in the secondary heart field has a clear role in cardiac arterial pole
development. In the absence of hedgehog signaling, proliferation is reduced in secondary …
development. In the absence of hedgehog signaling, proliferation is reduced in secondary …
[HTML][HTML] PDGFRβ is an essential therapeutic target for BRCA1-deficient mammary tumors
F Bai, S Liu, X Liu, DP Hollern, A Scott, C Wang… - Breast Cancer …, 2021 - Springer
Background Basal-like breast cancers (BLBCs) are a leading cause of cancer death due to
their capacity to metastasize and lack of effective therapies. More than half of BLBCs have a …
their capacity to metastasize and lack of effective therapies. More than half of BLBCs have a …
Intranasal oxytocin reduces weight gain in diet-induced obese prairie voles
…, MA Rhine, K Khun, AN Shweyk, AM Scott… - Physiology & …, 2018 - Elsevier
Oxytocin (OT) elicits weight loss in diet-induced obese (DIO) rodents, nonhuman primates
and humans by reducing food intake and increasing energy expenditure. In addition to being …
and humans by reducing food intake and increasing energy expenditure. In addition to being …
p16 loss rescues functional decline of Brca1-deficient mammary stem cells
Recent evidence indicates that the accumulation of endogenous DNA damage can induce
senescence and limit the function of adult stem cells. It remains elusive whether deficiency in …
senescence and limit the function of adult stem cells. It remains elusive whether deficiency in …
[HTML][HTML] p16INK4a suppresses BRCA1-deficient mammary tumorigenesis
Senescence prevents the proliferation of genomically damaged, but otherwise replication
competent cells at risk of neoplastic transformation. p16 INK4A (p16), an inhibitor of CDK4 and …
competent cells at risk of neoplastic transformation. p16 INK4A (p16), an inhibitor of CDK4 and …
[HTML][HTML] Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis
GATA3, a lineage specifier, controls lymphoid cell differentiation and its function in T cell
commitment and development has been extensively studied. GATA3 promotes T cell …
commitment and development has been extensively studied. GATA3 promotes T cell …