Stochastic rearrangement of germline V-, D-, and J-genes to create variable coding sequence
for certain cell surface receptors is at the origin of immune system diversity. This process, …

The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

High-throughput immune repertoire sequencing is promising to lead to new statistical diagnostic
tools for medicine and biology. Successful implementations of these methods require a …

Birds in a flock move in a correlated way, resulting in large polarization of velocities. A good
understanding of this collective behavior exists for linear motion of the flock. Yet observing …

In order to survive, reproduce, and (in multicellular organisms) differentiate, cells must control
the concentrations of the myriad different proteins that are encoded in the genome. The …

Flocking is a typical example of emergent collective behavior, where interactions between
individuals produce collective patterns on the large scale. Here we show how a quantitative …

T cell receptor (TCR) repertoire data contain information about infections that could be used
in disease diagnostics and vaccine development, but extracting that information remains a …

Recognition of pathogens relies on families of proteins showing great diversity. Here we
construct maximum entropy models of the sequence repertoire, building on recent experiments …

Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more
immunogenic cancer cells to cause less immunogenic clones to dominate a population. …

An exact steady-state solution of the stochastic equations governing the behavior of a gene
regulated by a self-generated proteomic atmosphere is presented. The solutions depend on …