Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

This article provides a review of research published since 1980 on the benefits of human–companion
animal interaction. Studies focusing on the benefits of pet ownership are …

Many common illnesses, for reasons that have not been identified, differentially affect men
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …

Newborn screening (NBS) dramatically improves outcomes in severe childhood disorders
by treatment before symptom onset. In many genetic diseases, however, outcomes remain …

Background Individual differences in initial sensitivity to ethanol are strongly related to the
heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate …

Long lasting abusive consumption, dependence, and withdrawal are characteristic features
of alcohol use disorders (AUD). Mechanistically, persistent changes in gene expression are …

While germline copy-number variants (CNVs) contribute to schizophrenia (SCZ) risk, the
contribution of somatic CNVs (sCNVs)—present in some but not all cells—remains unknown. …

Major depression (MD) is a debilitating mental health condition with peak prevalence occurring
early in life. Genome-wide examination of DNA methylation (DNAm) offers an attractive …

The bioactive sphingolipid sphingosine-1-phosphate (S1P) and the kinase that produces it
have been implicated in inflammatory bowel diseases in mice and humans; however, little is …