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Page 1
Base editing: advances and therapeutic opportunities.
Porto EM, Komor AC, Slaymaker IM, Yeo GW. Porto EM, et al. Among authors: slaymaker im. Nat Rev Drug Discov. 2020 Dec;19(12):839-859. doi: 10.1038/s41573-020-0084-6. Epub 2020 Oct 19. Nat Rev Drug Discov. 2020. PMID: 33077937 Free PMC article. Review.
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.
Zetsche B, Gootenberg JS, Abudayyeh OO, Slaymaker IM, Makarova KS, Essletzbichler P, Volz SE, Joung J, van der Oost J, Regev A, Koonin EV, Zhang F. Zetsche B, et al. Among authors: slaymaker im. Cell. 2015 Oct 22;163(3):759-71. doi: 10.1016/j.cell.2015.09.038. Epub 2015 Sep 25. Cell. 2015. PMID: 26422227 Free PMC article.
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.
Abudayyeh OO, Gootenberg JS, Konermann S, Joung J, Slaymaker IM, Cox DB, Shmakov S, Makarova KS, Semenova E, Minakhin L, Severinov K, Regev A, Lander ES, Koonin EV, Zhang F. Abudayyeh OO, et al. Among authors: slaymaker im. Science. 2016 Aug 5;353(6299):aaf5573. doi: 10.1126/science.aaf5573. Epub 2016 Jun 2. Science. 2016. PMID: 27256883 Free PMC article.
Directed evolution of adenine base editors with increased activity and therapeutic application.
Gaudelli NM, Lam DK, Rees HA, Solá-Esteves NM, Barrera LA, Born DA, Edwards A, Gehrke JM, Lee SJ, Liquori AJ, Murray R, Packer MS, Rinaldi C, Slaymaker IM, Yen J, Young LE, Ciaramella G. Gaudelli NM, et al. Among authors: slaymaker im. Nat Biotechnol. 2020 Jul;38(7):892-900. doi: 10.1038/s41587-020-0491-6. Epub 2020 Apr 13. Nat Biotechnol. 2020. PMID: 32284586
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.
Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, Zhang F, Nureki O. Yamano T, et al. Among authors: slaymaker im. Cell. 2016 May 5;165(4):949-62. doi: 10.1016/j.cell.2016.04.003. Epub 2016 Apr 21. Cell. 2016. PMID: 27114038 Free PMC article.
Engineering Cas9 for human genome editing.
Slaymaker IM, Gaudelli NM. Slaymaker IM, et al. Curr Opin Struct Biol. 2021 Aug;69:86-98. doi: 10.1016/j.sbi.2021.03.004. Epub 2021 May 5. Curr Opin Struct Biol. 2021. PMID: 33964614 Review.
CRISPR-Cas9 Mediated DNA Unwinding Detected Using Site-Directed Spin Labeling.
Tangprasertchai NS, Di Felice R, Zhang X, Slaymaker IM, Vazquez Reyes C, Jiang W, Rohs R, Qin PZ. Tangprasertchai NS, et al. Among authors: slaymaker im. ACS Chem Biol. 2017 Jun 16;12(6):1489-1493. doi: 10.1021/acschembio.6b01137. Epub 2017 May 3. ACS Chem Biol. 2017. PMID: 28437608 Free PMC article.
18 results