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DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation.
Morcom L, Gobius I, Marsh AP, Suárez R, Lim JW, Bridges C, Ye Y, Fenlon LR, Zagar Y, Douglass AM, Donahoo AS, Fothergill T, Shaikh S, Kozulin P, Edwards TJ, Cooper HM; IRC5 Consortium; Sherr EH, Chédotal A, Leventer RJ, Lockhart PJ, Richards LJ. Morcom L, et al. Elife. 2021 Apr 19;10:e61769. doi: 10.7554/eLife.61769. Elife. 2021. PMID: 33871356 Free PMC article.
Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance.
Marsh AP, Heron D, Edwards TJ, Quartier A, Galea C, Nava C, Rastetter A, Moutard ML, Anderson V, Bitoun P, Bunt J, Faudet A, Garel C, Gillies G, Gobius I, Guegan J, Heide S, Keren B, Lesne F, Lukic V, Mandelstam SA, McGillivray G, McIlroy A, Méneret A, Mignot C, Morcom LR, Odent S, Paolino A, Pope K, Riant F, Robinson GA, Spencer-Smith M, Srour M, Stephenson SE, Tankard R, Trouillard O, Welniarz Q, Wood A, Brice A, Rouleau G, Attié-Bitach T, Delatycki MB, Mandel JL, Amor DJ, Roze E, Piton A, Bahlo M, Billette de Villemeur T, Sherr EH, Leventer RJ, Richards LJ, Lockhart PJ, Depienne C. Marsh AP, et al. Among authors: morcom lr. Nat Genet. 2017 Apr;49(4):511-514. doi: 10.1038/ng.3794. Epub 2017 Feb 27. Nat Genet. 2017. PMID: 28250454 Free PMC article.
Development of body, head and brain features in the Australian fat-tailed dunnart (Sminthopsis crassicaudata; Marsupialia: Dasyuridae); A postnatal model of forebrain formation.
Suárez R, Paolino A, Kozulin P, Fenlon LR, Morcom LR, Englebright R, O'Hara PJ, Murray PJ, Richards LJ. Suárez R, et al. Among authors: morcom lr. PLoS One. 2017 Sep 7;12(9):e0184450. doi: 10.1371/journal.pone.0184450. eCollection 2017. PLoS One. 2017. PMID: 28880940 Free PMC article.