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2011 1
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Page 1
Genome engineering at the dawn of the golden age.
Segal DJ, Meckler JF. Segal DJ, et al. Among authors: meckler jf. Annu Rev Genomics Hum Genet. 2013;14:135-58. doi: 10.1146/annurev-genom-091212-153435. Epub 2013 May 20. Annu Rev Genomics Hum Genet. 2013. PMID: 23701416 Review.
Quantitative analysis of TALE-DNA interactions suggests polarity effects.
Meckler JF, Bhakta MS, Kim MS, Ovadia R, Habrian CH, Zykovich A, Yu A, Lockwood SH, Morbitzer R, Elsäesser J, Lahaye T, Segal DJ, Baldwin EP. Meckler JF, et al. Nucleic Acids Res. 2013 Apr;41(7):4118-28. doi: 10.1093/nar/gkt085. Epub 2013 Feb 13. Nucleic Acids Res. 2013. PMID: 23408851 Free PMC article.
Highly active zinc-finger nucleases by extended modular assembly.
Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal DJ. Bhakta MS, et al. Among authors: meckler jf. Genome Res. 2013 Mar;23(3):530-8. doi: 10.1101/gr.143693.112. Epub 2012 Dec 5. Genome Res. 2013. PMID: 23222846 Free PMC article.
Adding fingers to an engineered zinc finger nuclease can reduce activity.
Shimizu Y, Şöllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ. Shimizu Y, et al. Among authors: meckler jf. Biochemistry. 2011 Jun 7;50(22):5033-41. doi: 10.1021/bi200393g. Epub 2011 May 11. Biochemistry. 2011. PMID: 21528840 Free PMC article.