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Year Number of Results
1990 2
1998 4
1999 1
2000 3
2001 1
2002 1
2003 3
2004 1
2007 4
2008 3
2009 3
2010 2
2011 2
2012 1
2013 1
2014 2
2015 4
2016 4
2018 6
2019 1
2020 6
2021 7
2022 4
2023 2
2024 2

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64 results

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Page 1
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH. Fischer ES, et al. Among authors: hild m. Nature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16. Nature. 2014. PMID: 25043012 Free PMC article.
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F. Huang SM, et al. Among authors: hild m. Nature. 2009 Oct 1;461(7264):614-20. doi: 10.1038/nature08356. Epub 2009 Sep 16. Nature. 2009. PMID: 19759537
Bidirectional transport of amino acids regulates mTOR and autophagy.
Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, Finan PM, Murphy LO. Nicklin P, et al. Among authors: hild m. Cell. 2009 Feb 6;136(3):521-34. doi: 10.1016/j.cell.2008.11.044. Cell. 2009. PMID: 19203585 Free PMC article.
An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion.
Keller CG, Shin Y, Monteys AM, Renaud N, Beibel M, Teider N, Peters T, Faller T, St-Cyr S, Knehr J, Roma G, Reyes A, Hild M, Lukashev D, Theil D, Dales N, Cha JH, Borowsky B, Dolmetsch R, Davidson BL, Sivasankaran R. Keller CG, et al. Among authors: hild m. Nat Commun. 2022 Mar 3;13(1):1150. doi: 10.1038/s41467-022-28653-6. Nat Commun. 2022. PMID: 35241644 Free PMC article.
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery.
Li J, Ho DJ, Henault M, Yang C, Neri M, Ge R, Renner S, Mansur L, Lindeman A, Kelly B, Tumkaya T, Ke X, Soler-Llavina G, Shanker G, Russ C, Hild M, Gubser Keller C, Jenkins JL, Worringer KA, Sigoillot FD, Ihry RJ. Li J, et al. Among authors: hild m. ACS Chem Biol. 2022 Jun 17;17(6):1401-1414. doi: 10.1021/acschembio.1c00920. Epub 2022 May 4. ACS Chem Biol. 2022. PMID: 35508359 Free PMC article.
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.
Cho H, Shen Q, Zhang LH, Okumura M, Kawakami A, Ambrose J, Sigoillot F, Miller HR, Gleim S, Cobos-Correa A, Wang Y, Piechon P, Roma G, Eggimann F, Moore C, Aspesi P Jr, Mapa FA, Burks H, Ross NT, Krastel P, Hild M, Maimone TJ, Fisher DE, Nomura DK, Tallarico JA, Canham SM, Jenkins JL, Forrester WC. Cho H, et al. Among authors: hild m. Cell Chem Biol. 2021 Oct 21;28(10):1407-1419.e6. doi: 10.1016/j.chembiol.2021.03.004. Epub 2021 Mar 31. Cell Chem Biol. 2021. PMID: 33794192 Free PMC article.
64 results