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C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress.
Nature. 2017 Feb 16;542(7641):367-371. doi: 10.1038/nature21362. Epub 2017 Feb 8.
Nature. 2017.
PMID: 28178240
Free PMC article.
Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers.
Arnold ML, Cooper J, Androwski R, Ardeshna S, Melentijevic I, Smart J, Guasp RJ, Nguyen KCQ, Bai G, Hall DH, Grant BD, Driscoll M.
Arnold ML, et al. Among authors: guasp rj.
Nat Commun. 2023 Jul 24;14(1):4450. doi: 10.1038/s41467-023-39700-1.
Nat Commun. 2023.
PMID: 37488107
Free PMC article.
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Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling.
Cooper JF, Guasp RJ, Arnold ML, Grant BD, Driscoll M.
Cooper JF, et al. Among authors: guasp rj.
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2101410118. doi: 10.1073/pnas.2101410118.
Proc Natl Acad Sci U S A. 2021.
PMID: 34475208
Free PMC article.
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