Genetic influence on perceptions of major events later in life was assessed with a combination of twin and adoption designs as part of the Swedish Adoption/Twin Study of Aging (SATSA). The SATSA design includes 4 groups totaling 399 pairs of same-sex twins: identical and fraternal twins reared apart and matched twins reared together. The average age of the twins was 59 years. The results demonstrate significant genetic influence on reports of the occurrence of life events, especially for controllable events in which the individual can play an active role. Maximum likelihood model-fitting estimates of genetic influence indicate that 40% of the variance of the total life events score is due to genetic differences among individuals. How genetic factors can affect life experiences and directions for future research are discussed.