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Spontaneous Mutation: Genetic Control of Mutation Rates in Bacteriophage T4

Abstract

The following two articles are concerned with the genetic control of mutation rate. The first describes the anti-mutagenic effect of some DNA polymerase mutations on phage T4 mutation rates, and discusses the implications they hold for the mechanism of action of DNA polymerase. The second compares spontaneous mutation rates in different species, and considers the biological factors which may determine these rates.

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References

  1. Speyer, J. F., Biochem. Biophys. Res. Commun., 21, 6 (1965).

    Article  CAS  PubMed  Google Scholar 

  2. Drake, J. W., and Allen, E. F., Cold Spring Harbor Symp. Quant. Biol., 33 (in the press).

  3. Bernstein, H., Genetics, 56, 755 (1967).

    PubMed  PubMed Central  CAS  Google Scholar 

  4. Edgar, R. S., Denhardt, G. H., and Epstein, R. H., Genetics, 49, 635 (1964).

    PubMed  PubMed Central  CAS  Google Scholar 

  5. Fincham, J. R. S., Genetic Complementation (W. A. Benjamin, Inc., New York and Amsterdam, 1966).

    Google Scholar 

  6. Drake, J. W., An Introduction to the Molecular Basis of Mutation (Holden-Day, San Francisco, in the press).

  7. Speyer, J. F., Karam, J. D., and Lenny, A. B., Cold Spring Harbor Symp. Quant. Biol., 31, 693 (1966).

    Article  CAS  PubMed  Google Scholar 

  8. Benzer, S., Proc. US Nat. Acad. Sci., 41, 344 (1955).

    Article  ADS  CAS  Google Scholar 

  9. Luria, S. E., Cold Spring Harbor Symp. Quant. Biol., 16, 463 (1951).

    Article  CAS  PubMed  Google Scholar 

  10. Stretton, A. O. W., Kaplan, S., and Brenner, S., Cold Spring Harbor Symp. Quant. Biol., 31, 173 (1966).

    Article  CAS  PubMed  Google Scholar 

  11. Freese, E. B., and Freese, E., Proc. US Nat. Acad. Sci., 57, 650 (1967).

    Article  ADS  CAS  Google Scholar 

  12. Green, D. M., and Krieg, D. R., Proc. US Nat. Acad. Sci., 47, 65 (1961).

    Article  Google Scholar 

  13. Phillips, J. H., Brown, D. M., and Grossman, L., J. Mol. Biol., 21, 405 (1966).

    Article  CAS  Google Scholar 

  14. Baker, R., and Tessman, I., J. Mol. Biol., 35, 439 (1968).

    Article  CAS  Google Scholar 

  15. Stahl, F. W., Edgar, R. S., and Steinberg, J., Genetics, 50, 539 (1964).

    PubMed  PubMed Central  CAS  Google Scholar 

  16. Whitfield, H. J., Martin, R. G., and Ames, B. N., J. Mol. Biol., 21, 335 (1966).

    Article  CAS  PubMed  Google Scholar 

  17. Margolies, M. N., and Goldberger, R. F., J. Bacteriol., 95, 507 (1968).

    PubMed  PubMed Central  CAS  Google Scholar 

  18. Malamy, M. H., Cold Spring Harbor Symp. Quant. Biol., 31, 189 (1966).

    Article  CAS  PubMed  Google Scholar 

  19. Drake, J. W., J. Mol. Biol., 6, 268 (1963).

    Article  CAS  Google Scholar 

  20. Drake, J. W., and McGuire, J., Genetics, 55, 387 (1967).

    PubMed  PubMed Central  CAS  Google Scholar 

  21. Tessman, I., Virology, 35, 330 (1968).

    Article  CAS  PubMed  Google Scholar 

Download references

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DRAKE, J., ALLEN, E., FORSBERG, S. et al. Spontaneous Mutation: Genetic Control of Mutation Rates in Bacteriophage T4. Nature 221, 1128–1132 (1969). https://doi.org/10.1038/2211128a0

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