Abstract
The following two articles are concerned with the genetic control of mutation rate. The first describes the anti-mutagenic effect of some DNA polymerase mutations on phage T4 mutation rates, and discusses the implications they hold for the mechanism of action of DNA polymerase. The second compares spontaneous mutation rates in different species, and considers the biological factors which may determine these rates.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Speyer, J. F., Biochem. Biophys. Res. Commun., 21, 6 (1965).
Drake, J. W., and Allen, E. F., Cold Spring Harbor Symp. Quant. Biol., 33 (in the press).
Bernstein, H., Genetics, 56, 755 (1967).
Edgar, R. S., Denhardt, G. H., and Epstein, R. H., Genetics, 49, 635 (1964).
Fincham, J. R. S., Genetic Complementation (W. A. Benjamin, Inc., New York and Amsterdam, 1966).
Drake, J. W., An Introduction to the Molecular Basis of Mutation (Holden-Day, San Francisco, in the press).
Speyer, J. F., Karam, J. D., and Lenny, A. B., Cold Spring Harbor Symp. Quant. Biol., 31, 693 (1966).
Benzer, S., Proc. US Nat. Acad. Sci., 41, 344 (1955).
Luria, S. E., Cold Spring Harbor Symp. Quant. Biol., 16, 463 (1951).
Stretton, A. O. W., Kaplan, S., and Brenner, S., Cold Spring Harbor Symp. Quant. Biol., 31, 173 (1966).
Freese, E. B., and Freese, E., Proc. US Nat. Acad. Sci., 57, 650 (1967).
Green, D. M., and Krieg, D. R., Proc. US Nat. Acad. Sci., 47, 65 (1961).
Phillips, J. H., Brown, D. M., and Grossman, L., J. Mol. Biol., 21, 405 (1966).
Baker, R., and Tessman, I., J. Mol. Biol., 35, 439 (1968).
Stahl, F. W., Edgar, R. S., and Steinberg, J., Genetics, 50, 539 (1964).
Whitfield, H. J., Martin, R. G., and Ames, B. N., J. Mol. Biol., 21, 335 (1966).
Margolies, M. N., and Goldberger, R. F., J. Bacteriol., 95, 507 (1968).
Malamy, M. H., Cold Spring Harbor Symp. Quant. Biol., 31, 189 (1966).
Drake, J. W., J. Mol. Biol., 6, 268 (1963).
Drake, J. W., and McGuire, J., Genetics, 55, 387 (1967).
Tessman, I., Virology, 35, 330 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DRAKE, J., ALLEN, E., FORSBERG, S. et al. Spontaneous Mutation: Genetic Control of Mutation Rates in Bacteriophage T4. Nature 221, 1128–1132 (1969). https://doi.org/10.1038/2211128a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2211128a0
This article is cited by
-
Mutators and hypermutability in bacteria: the Escherichia coli paradigm
Journal of Genetics (2009)
-
A Case of Gene Controlled Mutational Stability in Escherichia coli B
Journal of Plant Biochemistry and Biotechnology (1992)
-
Isolation and genetic characterization of newuvsW alleles of bacteriophage T4
Molecular and General Genetics MGG (1990)
-
Bacteriophage T4 DNA polymerase determines the amount and specificity of ultraviolet mutagenesis
Molecular and General Genetics MGG (1988)
-
DNA sequence analysis of spontaneous mutation in a PolA1 strain of Escherichia coli indicates sequence-specific effects
Molecular and General Genetics MGG (1987)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.