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Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells
View ORCID ProfileSameer S. Chopra, Anne Jenney, Adam Palmer, Mario Niepel, Mirra Chung, Caitlin Mills, Sindhu Carmen Sivakumaren, Qingsong Liu, Jia-Yun Chen, Clarence Yapp, John M. Asara, Nathanael S. Gray, Peter K. Sorger
doi: https://doi.org/10.1101/700625
Sameer S. Chopra
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Anne Jenney
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Adam Palmer
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Mario Niepel
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Mirra Chung
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Caitlin Mills
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Sindhu Carmen Sivakumaren
2Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Qingsong Liu
2Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Jia-Yun Chen
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Clarence Yapp
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
John M. Asara
4Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Nathanael S. Gray
2Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
5Dana-Farber Cancer Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
Peter K. Sorger
1Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
3Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted July 12, 2019.
Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells
Sameer S. Chopra, Anne Jenney, Adam Palmer, Mario Niepel, Mirra Chung, Caitlin Mills, Sindhu Carmen Sivakumaren, Qingsong Liu, Jia-Yun Chen, Clarence Yapp, John M. Asara, Nathanael S. Gray, Peter K. Sorger
bioRxiv 700625; doi: https://doi.org/10.1101/700625
Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells
Sameer S. Chopra, Anne Jenney, Adam Palmer, Mario Niepel, Mirra Chung, Caitlin Mills, Sindhu Carmen Sivakumaren, Qingsong Liu, Jia-Yun Chen, Clarence Yapp, John M. Asara, Nathanael S. Gray, Peter K. Sorger
bioRxiv 700625; doi: https://doi.org/10.1101/700625
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