@article {Gallaher036467, author = {Jill Gallaher, Jr and Alexander R.A. Anderson}, title = {The role of contact inhibition in intratumoral heterogeneity: An off-lattice individual based model}, elocation-id = {036467}, year = {2016}, doi = {10.1101/036467}, publisher = {Cold Spring Harbor Laboratory}, abstract = {We present a model that shows how intratumoral heterogeneity, in terms of tumor cell phenotypic traits, can evolve in a tumor mass as a result of selection when space is a limited resource. This model specifically looks at the traits of proliferation rate and migration speed. The competition for space amongst individuals in the tumor mass creates a selection pressure for the cells with the fittest traits. To allow for organic movement and capture the invasive behavior, we use an off-lattice individual-based model.}, URL = {https://www.biorxiv.org/content/early/2016/01/11/036467}, eprint = {https://www.biorxiv.org/content/early/2016/01/11/036467.full.pdf}, journal = {bioRxiv} }