TY - JOUR T1 - Mergeomics: integration of diverse genomics resources to identify pathogenic perturbations to biological systems JF - bioRxiv DO - 10.1101/036012 SP - 036012 AU - Le Shu AU - Yuqi Zhao AU - Zeyneb Kurt AU - Sean Geoffrey Byars AU - Taru Tukiainen AU - Johannes Kettunen AU - Samuli Ripatti AU - Bin Zhang AU - Michael Inouye AU - Ville-Petteri Mäkinen AU - Xia Yang Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/01/07/036012.abstract N2 - Mergeomics is a computational pipeline (http://mergeomics.research.idre.ucla.edu/Download/Package/) that integrates multidimensional omics-disease associations, functional genomics, canonical pathways and gene-gene interaction networks to generate mechanistic hypotheses. It first identifies biological pathways and tissue-specific gene subnetworks that are perturbed by disease-associated molecular entities. The disease-associated subnetworks are then projected onto tissue-specific gene-gene interaction networks to identify local hubs as potential key drivers of pathological perturbations. The pipeline is modular and can be applied across species and platform boundaries, and uniquely conducts pathway/network level meta-analysis of multiple genomic studies of various data types. Application of Mergeomics to cholesterol datasets revealed novel regulators of cholesterol metabolism. ER -