PT - JOURNAL ARTICLE AU - Eduardo D. Sontag TI - Incoherent feedforward motifs as immune change detectors AID - 10.1101/035600 DP - 2015 Jan 01 TA - bioRxiv PG - 035600 4099 - http://biorxiv.org/content/early/2015/12/30/035600.short 4100 - http://biorxiv.org/content/early/2015/12/30/035600.full AB - We speculate that incoherent feedforward loops may be phenomenologically involved in self/nonself discrimination in immune-infection and immune-tumor interactions, acting as “change detectors”. In turn, this may result in logarithmic sensing (Weber phenomenon) and even scale invariance (fold-change detection).