PT  - JOURNAL ARTICLE
AU  - Yuriy Mishchenko
TI  - Variability in cellular gene expression profiles and homeostatic regulation
AID  - 10.1101/021048
DP  - 2015 Jan 01
TA  - bioRxiv
PG  - 021048
4099  - http://biorxiv.org/content/early/2015/12/25/021048.short
4100  - http://biorxiv.org/content/early/2015/12/25/021048.full
AB  - One of surprising recent discoveries in biology is that the gene and protein expression profiles in cells with identical genetic and environmental makeup can exhibit large variability. The nature and the significance of this variability had been posed as one of the current fundamental questions of biology. In this letter, we argue that the observed variability in cellular gene and protein expression can be understood as an outcome of homeostatic regulation mechanisms controlling the gene and protein expression profiles.