PT  - JOURNAL ARTICLE
AU  - Yuan-De Tan
TI  - Recombination Disequilibrium in Ideal and Natural Populations
AID  - 10.1101/035121
DP  - 2015 Jan 01
TA  - bioRxiv
PG  - 035121
4099  - http://biorxiv.org/content/early/2015/12/24/035121.short
4100  - http://biorxiv.org/content/early/2015/12/24/035121.full
AB  - Following Hardy-Weinberg disequilibrium (HWD) occurring at a single locus and linkage disequilibrium (LD) between two loci in generations, we here proposed the third genetic disequilibrium in population: recombination disequilibrium (RD). RD is a measurement of crossover interference among multiple loci in a random mating population. In natural populations besides recombination interference, RD may also be due to selection, mutation, gene conversion, drift and/or migration. Therefore, similarly to LD, RD will also reflect the history of natural selection and mutation. In breeding populations, RD purely results from recombination interference and hence can be used to build or evaluate and correct a linkage map. Several practical examples from F2, testcross and human populations indeed demonstrate that RD is useful for measuring recombination interference between two short intervals and evaluating linkage maps. As with LD, RD will be important for studying genetic mapping, association of haplotypes with disease, plant breading and population history.