%0 Journal Article %A Shane McCarthy %A Sayantan Das %A Warren Kretzschmar %A Olivier Delaneau %A Andrew R. Wood %A Hyun Min Kang %A Christian Fuchsberger %A Petr Danecek %A Kevin Sharp %A Yang Luo %A Carlo Sidore %A Alan Kwong %A Nicholas Timpson %A Seppo Koskinen %A Scott Vrieze %A Laura Scott %A He Zhang %A Anubha Mahajan %A Jan Veldink %A Ulrike Peters %A Carlos Pato %A Cornelia M. van Duijn %A Christopher E. Gillies %A Ilaria Gandin %A Massimo Mezzavilla %A Arthur Gilly %A Massimiliano Cocca %A Michela Traglia %A Andrea Angius %A Dorret I. Boomsma %A Kari Branham %A Chad Brummet %A Fabio Busonero %A Harry Campbell %A Andrew Chan %A Sai Chen %A Emily Chew %A Francis S. Collins %A George Davey Smith %A George Dedoussis %A Aliki-Eleni Farmaki %A Luigi Ferrucci %A Lukas Forer %A Ross M. Fraser %A Stacey Gabriel %A Shawn Levy %A Leif Groop %A Tabitha Harrison %A Andrew Hattersley %A Oddgeir L. Holmen %A Kristian Hveem %A Matthias Kretzler %A James Lee %A Matt McGue %A Thomas Meitinger %A David Melzer %A Josine Min %A Karen L. Mohlke %A John Vincent %A Gerome Breen %A Deborah Nickerson %A Aarno Palotie %A Michele Pato %A Nicola Pirastu %A Melvin McInnis %A Brent Richards %A Cinzia Sala %A Veikko Salomaa %A David Schlessinger %A Sebastian Schoenheer %A P Eline Slagboom %A Kerrin Small %A Timothy Spector %A Dwight Stambolian %A Marcus Tuke %A Jaakko Tuomilehto %A Leonard Van den Berg %A Wouter Van Rheenen %A Cisca Wijmenga %A Daniela Toniolo %A Eleftheria Zeggini %A Paolo Gasparini %A Matthew G. Sampson %A James F. Wilson %A Timothy Frayling %A Paul de Bakker %A Morris A. Swertz %A Steven McCarroll %A Charles Kooperberg %A Annelot Dekker %A David Altshuler %A Cristen Willer %A William Iacono %A Samuli Ripatti %A Nicole Soranzo %A Klaudia Walter %A Anand Swaroop %A Francesco Cucca %A Carl Anderson %A Michael Boehnke %A Mark I. McCarthy %A Richard Durbin %A Goncalo Abecasis %A Jonathan Marchini %T A reference panel of 64,976 haplotypes for genotype imputation %D 2015 %R 10.1101/035170 %J bioRxiv %P 035170 %X We describe a reference panel of 64,976 haplotypes at 39,235,157 SNPs constructed using whole genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1%, a large increase in the number of SNPs tested in association studies and can help to refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently. %U https://www.biorxiv.org/content/biorxiv/early/2015/12/23/035170.full.pdf