PT  - JOURNAL ARTICLE
AU  - Liya Wang
AU  - Peter Van Buren
AU  - Doreen Ware
TI  - Architecting a distributed bioinformatics platform with iRODS and iPlant Agave API
AID  - 10.1101/034488
DP  - 2015 Jan 01
TA  - bioRxiv
PG  - 034488
4099  - http://biorxiv.org/content/early/2015/12/15/034488.short
4100  - http://biorxiv.org/content/early/2015/12/15/034488.full
AB  - Over the past few years, cloud-based platforms have been proposed to address storage, management, and computation of large-scale data, especially in the field of genomics. However, for collaboration efforts involving multiple institutes, data transfer and management, interoperability and standardization among different platforms have imposed new challenges. This paper proposes a distributed bioinformatics platform that can leverage local clusters with remote computational clusters for genomic analysis using the unified bioinformatics workflow. The platform is built with a data server configured with iRODS, a computation cluster authenticated with iPlant Agave system, and web server to interact with the platform. A Genome-Wide Association Study workflow is integrated to validate the feasibility of the proposed approach.