%0 Journal Article %A Ying Zhou %A Hongxiang Qiu %A Shuhua Xu %T Modeling Continuous Admixture %D 2015 %R 10.1101/033944 %J bioRxiv %P 033944 %X Human migration and human isolation serve as the driving forces of modern human civilization. Recent migrations of long isolated populations have resulted in genetically admixed populations. The history of population admixture is generally complex; however, understanding the admixture process is critical to both evolutionary and medical studies. Here, we utilized admixture induced linkage disequilibrium (LD) to infer occurrence of continuous admixture events, which is common for most existing admixed populations. Unlike previous studies, we expanded the typical continuous admixture model to a more general admixture scenario with isolation after a certain duration of continuous gene flow. Based on the extended models, we developed a method based on weighted LD to infer the admixture history considering continuous and complex demographic process of gene flow between populations. We evaluated the performance of the method by computer simulation and applied our method to real data analysis of a few well-known admixed populations. %U https://www.biorxiv.org/content/biorxiv/early/2015/12/08/033944.full.pdf