TY - JOUR T1 - Principles of ipsilateral and contralateral cortico-cortical connectivity in the mouse JF - bioRxiv DO - 10.1101/033878 SP - 033878 AU - Alexandros Goulas AU - Harry BM Uylings AU - Claus C Hilgetag Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/12/07/033878.abstract N2 - Structural connectivity among cortical areas provides the substrate for information exchange in the brain and is characterized by the presence or absence of connections between specific areas. What principles govern this cortical wiring diagram? Here, we investigate the relation of physical distance and cytoarchitecture with the connectional architecture of the mouse cortex. Moreover, we examine the relation between patterns of ipsilateral and contralateral connections. Our analysis reveals a mirrored and attenuated organization of contralateral connections when compared to ipsilateral connections. Both spatial proximity and cytoarchitectonic similarity of cortical areas are related to the presence or absence of connections. Notably, our analysis demonstrated that these factors conjointly relate better to cortico-cortical connectivity than each factor in isolation, and that the two factors contribute differently to ipsilateral and contralateral connectivity. Distance is more tightly related to the presence or absence of ipsilateral connections, but its contribution greatly diminishes for contralateral connections, while the contribution of cytoarchitectonic similarity remains stable. Our results, conjointly with similar findings in the cat and macaque cortex, suggest that a common set of principles underlies the macroscale wiring of mammalian brains. ER -