RT Journal Article
SR Electronic
T1 Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 032789
DO 10.1101/032789
A1 Aysu Okbay
A1 Bart M.L. Baselmans
A1 Jan-Emmanuel De Neve
A1 Patrick Turley
A1 Michel G. Nivard
A1 Mark A. Fontana
A1 S. Fleur W. Meddens
A1 Richard Karlsson Linnér
A1 Cornelius A. Rietveld
A1 Jaime Derringer
A1 Jacob Gratten
A1 James J. Lee
A1 Jimmy Z. Liu
A1 Ronald de Vlaming
A1 Tarunveer S. Ahluwalia
A1 Jadwiga Buchwald
A1 Alana Cavadino
A1 Alexis C. Frazier-Wood
A1 Nicholas A. Furlotte
A1 Victoria Garfield
A1 Marie Henrike Geisel
A1 Juan R. Gonzalez
A1 Saskia Haitjema
A1 Robert Karlsson
A1 Sander W. van der Laan
A1 Karl-Heinz Ladwig
A1 Jari Lahti
A1 Sven J. van der Lee
A1 Penelope A. Lind
A1 Tian Liu
A1 Lindsay Matteson
A1 Evelin Mihailov
A1 Michael B. Miller
A1 Camelia C. Minica
A1 Ilja M. Nolte
A1 Dennis Mook-Kanamori
A1 Peter J. van der Most
A1 Christopher Oldmeadow
A1 Yong Qian
A1 Olli Raitakari
A1 Rajesh Rawal
A1 Anu Realo
A1 Rico Rueedi
A1 Börge Schmidt
A1 Albert V. Smith
A1 Evie Stergiakouli
A1 Toshiko Tanaka
A1 Kent Taylor
A1 Juho Wedenoja
A1 Juergen Wellmann
A1 Harm-Jan Westra
A1 Sara M. Willems
A1 Wei Zhao
A1 Behrooz Z. Alizadeh
A1 Najaf Amin
A1 Andrew Bakshi
A1 Patricia A. Boyle
A1 Simon Cox
A1 Gail Davies
A1 Oliver S.P. Davis
A1 Jun Ding
A1 Nese Direk
A1 Peter Eibich
A1 Rebecca T. Emeny
A1 Ghazaleh Fatemifar
A1 Jessica D. Faul
A1 Luigi Ferrucci
A1 Andreas J. Forstner
A1 Christian Gieger
A1 Tamara B. Harris
A1 Juliette M. Harris
A1 Elizabeth G. Holliday
A1 Jouke-Jan Hottenga
A1 Philip L. De Jager
A1 Marika A. Kaakinen
A1 Eero Kajantie
A1 Ville Karhunen
A1 Ivana Kolcic
A1 Meena Kumari
A1 Lenore J. Launer
A1 LifeLines Cohort Study
A1 Ruifang Li-Gao
A1 Marisa Loitfelder
A1 Anu Loukola
A1 Pedro Marques-Vidal
A1 Grant W. Montgomery
A1 Lavinia Paternoster
A1 Alison Pattie
A1 Katja E. Petrovic
A1 Laura Pulkki-Råback
A1 Lydia Quaye
A1 Katri Räikkönen
A1 Igor Rudan
A1 Rodney J. Scott
A1 Jennifer A. Smith
A1 Angelina R. Sutin
A1 Maciej Trzaskowski
A1 Anna E. Vinkhuyzen
A1 Lei Yu
A1 Delilah Zabaneh
A1 John R. Attia
A1 David A. Bennett
A1 Klaus Berger
A1 Lars Bertram
A1 Dorret I. Boomsma
A1 Ute Bultmann
A1 Shun-Chiao Chang
A1 Francesco Cucca
A1 Ian J. Deary
A1 Cornelia M. van Duijn
A1 Johan G. Eriksson
A1 Lude Franke
A1 Eco J.C. de Geus
A1 Patrick J.F. Groenen
A1 Vilmundur Gudnason
A1 Torben Hansen
A1 Catharine A. Hartman
A1 Claire M.A. Haworth
A1 Caroline Hayward
A1 Andrew C. Heath
A1 David A. Hinds
A1 Elina Hyppönen
A1 William G. Iacono
A1 Marjo-Riitta Järvelin
A1 Karl-Heinz Jöckel
A1 Jaakko Kaprio
A1 Sharon L.R. Kardia
A1 Liisa Keltikangas-Järvinen
A1 Peter Kraft
A1 Laura Kubzansky
A1 Terho Lehtimäki
A1 Patrik K.E. Magnusson
A1 Nicholas G. Martin
A1 Matt McGue
A1 Andres Metspalu
A1 Melinda Mills
A1 Renée de Mutsert
A1 Albertine J. Oldehinkel
A1 Gerard Pasterkamp
A1 Nancy L. Pedersen
A1 Robert Plomin
A1 Ozren Polasek
A1 Christine Power
A1 Stephen S. Rich
A1 Frits R. Rosendaal
A1 Hester M. den Ruijter
A1 David Schlessinger
A1 Helena Schmidt
A1 Rauli Svento
A1 Reinhold Schmidt
A1 Harold Snieder
A1 Thorkild I.A. Sørensen
A1 Tim D. Spector
A1 Andrew Steptoe
A1 Antonio Terracciano
A1 A. Roy Thurik
A1 Nicholas J. Timpson
A1 Henning Tiemeier
A1 André G. Uitterlinden
A1 Peter Vollenweider
A1 Gert Wagner
A1 David R. Weir
A1 Jian Yang
A1 Dalton C. Conley
A1 George Davey Smith
A1 Albert Hofman
A1 Magnus Johannesson
A1 David I. Laibson
A1 Sarah E. Medland
A1 Michelle N. Meyer
A1 Joseph K. Pickrell
A1 Tõnu Esko
A1 Robert F. Krueger
A1 Jonathan P. Beauchamp
A1 Philipp D. Koellinger
A1 Daniel J. Benjamin
A1 Meike Bartels
A1 David Cesarini
YR 2015
UL http://biorxiv.org/content/early/2015/11/24/032789.abstract
AB We conducted a genome-wide association study of subjective well-being (SWB) in 298,420 individuals. We also performed auxiliary analyses of depressive symptoms (“DS”; N = 161,460) and neuroticism (N = 170,910), both of which have a substantial genetic correlation with SWB . We identify three SNPs associated with SWB at genome-wide significance. Two of them are significantly associated with DS in an independent sample. In our auxiliary analyses, we identify 13 additional genome-wide-significant associations: two with DS and eleven with neuroticism, including two inversion polymorphisms. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are enriched. The discovery of genetic loci associated with the three phenotypes we study has proven elusive; our findings illustrate the payoffs from studying them jointly.One Sentence Summary: Using both genome-wide association studies and proxy-phenotype studies, we identify genetic variants associated with subjective well-being, depressive symptoms, and neuroticism.