RT Journal Article
SR Electronic
T1 Expression weighted cell type enrichments reveal genetic and cellular nature of major brain disorders
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 032680
DO 10.1101/032680
A1 Nathan G. Skene
A1 Seth G.N. Grant
YR 2015
UL http://biorxiv.org/content/early/2015/11/23/032680.abstract
AB The cell types which trigger the primary pathology in many major brain diseases remains unknown. Correspondingly, many open questions remain regarding which cells are phenotypically disturbed in the same disorders. We report a new method, Expression Weighted Cell Type Enrichment (EWCE), which utilizes single cell transcriptomes to generate robust answers to both questions. We find that three major disorders show evidence of a primary microglial origin. Through post-mortem transcriptomes we find that Autism, Schizophrenia and Alzheimer’s are found to show robustly detectable phenotypes across most of the major brain cell types.