@article {Skene032680, author = {Nathan G. Skene and Seth G.N. Grant}, title = {Expression weighted cell type enrichments reveal genetic and cellular nature of major brain disorders}, elocation-id = {032680}, year = {2015}, doi = {10.1101/032680}, publisher = {Cold Spring Harbor Laboratory}, abstract = {The cell types which trigger the primary pathology in many major brain diseases remains unknown. Correspondingly, many open questions remain regarding which cells are phenotypically disturbed in the same disorders. We report a new method, Expression Weighted Cell Type Enrichment (EWCE), which utilizes single cell transcriptomes to generate robust answers to both questions. We find that three major disorders show evidence of a primary microglial origin. Through post-mortem transcriptomes we find that Autism, Schizophrenia and Alzheimer{\textquoteright}s are found to show robustly detectable phenotypes across most of the major brain cell types.}, URL = {https://www.biorxiv.org/content/early/2015/11/23/032680}, eprint = {https://www.biorxiv.org/content/early/2015/11/23/032680.full.pdf}, journal = {bioRxiv} }