RT Journal Article
SR Electronic
T1 Genome-wide association and prediction reveals the genetic architecture of cassava mosaic disease resistance and prospects for rapid genetic improvement
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 031179
DO 10.1101/031179
A1 Marnin D. Wolfe
A1 Ismail Y. Rabbi
A1 Chiedozie Egesi
A1 Martha Hamblin
A1 Robert Kawuki
A1 Peter Kulakow
A1 Roberto Lozano
A1 Dunia Pino Del Carpio
A1 Punna Ramu
A1 Jean-Luc Jannink
YR 2015
UL http://biorxiv.org/content/early/2015/11/11/031179.abstract
AB Cassava (Manihot esculenta) is a crucial, under-researched crop feeding millions worldwide, especially in Africa. Cassava mosaic disease (CMD) has plagued production in Africa for over a century. Bi-parental mapping studies suggest primarily a single major gene mediates resistance. To be certain and to potentially identify new loci we conducted the first genome-wide association mapping study in cassava with 6128 African breeding lines. We also assessed the accuracy of genomic selection to improve CMD resistance. We found a single region on chromosome 8 accounts for most resistance but also identified 13 small effect regions. We found evidence that two epistatic loci and/or alternatively multiple resistance alleles exist at major QTL. We identified two peroxidases and one thioredoxin as candidate genes. Genomic prediction of additive and total genetic merit was accurate for CMD and will be effective both for selecting parents and identifying highly resistant clones as varieties.