RT Journal Article
SR Electronic
T1 Micro-Pharmacodynamics: Bridging In Vitro and In Vivo Experimental Scales in Testing Drug Efficacy and Resistance
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 031294
DO 10.1101/031294
A1 Katarzyna A. Rejniak
YR 2015
UL http://biorxiv.org/content/early/2015/11/11/031294.abstract
AB Systemic chemotherapy is one of the main anticancer treatments used for most kinds of clinically diagnosed tumors. However, the efficacy of these drugs can be hampered by the physical attributes of the tumor tissue that can impede the transport of therapeutic agents to tumor cells in sufficient quantities. As a result, drugs that work well in vitro often fail at clinical trials when confronted with the complexities of interstitial transport within the tumor microenvironment. The microPD model that we developed is used to investigate the penetration of drug molecules through the tumor tissue and influenced by the physical and metabolic properties of tumor microenvironment, and how it affects drug efficacy and the emergence of drug resistance.