PT  - JOURNAL ARTICLE
AU  - Arturas Ziemys
AU  - Milos Kojic
AU  - Mauro Ferrari
TI  - Physics-based multiscale mass transport model in drug delivery and tumor microenvironment
AID  - 10.1101/031252
DP  - 2015 Jan 01
TA  - bioRxiv
PG  - 031252
4099  - http://biorxiv.org/content/early/2015/11/10/031252.short
4100  - http://biorxiv.org/content/early/2015/11/10/031252.full
AB  - We describe multiscale transport model, which was developed to simulate drug diffusion and convection in tissues and drug vectors. Models rely on material properties and physical laws of transport. Our methods show that drug transport analysis may provide deep insight into mechanisms of pharmacokinetics useful in nanotherapeutics and transport study within tumor microenvironment. Because the method relies on material properties and structures, the approach can help studying phenotypical differences as well.