TY - JOUR T1 - Modeling Transitions between Responsive and Resistant States in Breast Cancer with Application to Therapy Optimization JF - bioRxiv DO - 10.1101/031245 SP - 031245 AU - Chun Chen AU - John J. Tyson AU - William T. Baumann Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/11/10/031245.abstract N2 - We present a mathematical model that captures the transitions among three experimentally observed estrogen-sensitivity phenotypes in breast cancer cells. Based on this model, a population-level model is created and used to explore the optimization of a therapeutic protocol ER -