PT  - JOURNAL ARTICLE
AU  - Chun Chen
AU  - John J. Tyson
AU  - William T. Baumann
TI  - Modeling Transitions between Responsive and Resistant States in Breast Cancer with Application to Therapy Optimization
AID  - 10.1101/031245
DP  - 2015 Jan 01
TA  - bioRxiv
PG  - 031245
4099  - http://biorxiv.org/content/early/2015/11/10/031245.short
4100  - http://biorxiv.org/content/early/2015/11/10/031245.full
AB  - We present a mathematical model that captures the transitions among three experimentally observed estrogen-sensitivity phenotypes in breast cancer cells. Based on this model, a population-level model is created and used to explore the optimization of a therapeutic protocol