%0 Journal Article %A Chun Chen %A John J. Tyson %A William T. Baumann %T Modeling Transitions between Responsive and Resistant States in Breast Cancer with Application to Therapy Optimization %D 2015 %R 10.1101/031245 %J bioRxiv %P 031245 %X We present a mathematical model that captures the transitions among three experimentally observed estrogen-sensitivity phenotypes in breast cancer cells. Based on this model, a population-level model is created and used to explore the optimization of a therapeutic protocol %U https://www.biorxiv.org/content/biorxiv/early/2015/11/10/031245.full.pdf