@article {Chen031245, author = {Chun Chen and John J. Tyson and William T. Baumann}, title = {Modeling Transitions between Responsive and Resistant States in Breast Cancer with Application to Therapy Optimization}, elocation-id = {031245}, year = {2015}, doi = {10.1101/031245}, publisher = {Cold Spring Harbor Laboratory}, abstract = {We present a mathematical model that captures the transitions among three experimentally observed estrogen-sensitivity phenotypes in breast cancer cells. Based on this model, a population-level model is created and used to explore the optimization of a therapeutic protocol}, URL = {https://www.biorxiv.org/content/early/2015/11/10/031245}, eprint = {https://www.biorxiv.org/content/early/2015/11/10/031245.full.pdf}, journal = {bioRxiv} }