RT Journal Article
SR Electronic
T1 Understanding stem cell states: naïve to primed pluripotency in rodents and humans
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 030676
DO 10.1101/030676
A1 Leehee Weinberger
A1 Muneef Ayyash
A1 Noa Novershtern
A1 Jacob H. Hanna
YR 2015
UL http://biorxiv.org/content/early/2015/11/06/030676.abstract
AB The molecular mechanisms and signalling pathways that regulate the in vitro preservation of distinct pluripotent stem cell configurations, and their induction in somatic cells via direct reprogramming approaches, continue to constitute a highly exciting area of research. In this Review, we provide an integrative synthesis on recent discoveries related to isolating unique naïve and primed pluripotent stem cell states with altered functional and molecular characteristics, and from different species. We overview pathways underlying pluripotent state transitions and interconversion in vitro and in vivo. We conclude by highlighting unresolved key questions, future directions and potential novel applications of such pluripotent cell states.