RT Journal Article SR Electronic T1 The UCSC Genome Browser database: 2016 update JF bioRxiv FD Cold Spring Harbor Laboratory SP 027037 DO 10.1101/027037 A1 Matthew L. Speir A1 Ann S. Zweig A1 Kate R. Rosenbloom A1 Brian J. Raney A1 Benedict Paten A1 Parisa Nejad A1 Brian T. Lee A1 Katrina Learned A1 Donna Karolchik A1 Angie S. Hinrichs A1 Steve Heitner A1 Rachel A. Harte A1 Maximilian Haeussler A1 Luvina Guruvadoo A1 Pauline A. Fujita A1 Christopher Eisenhart A1 Mark Diekhans A1 Hiram Clawson A1 Jonathan Casper A1 Galt P. Barber A1 David Haussler A1 Robert M. Kuhn A1 W. James Kent YR 2015 UL http://biorxiv.org/content/early/2015/11/06/027037.abstract AB For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the “Data Integrator”, for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment.