RT Journal Article
SR Electronic
T1 Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 030288
DO 10.1101/030288
A1 Padhraig Gormley
A1 Verneri Anttila
A1 Bendik S Winsvold
A1 Priit Palta
A1 Tonu Esko
A1 Tune H. Pers
A1 Kai-How Farh
A1 Ester Cuenca-Leon
A1 Mikko Muona
A1 Nicholas A Furlotte
A1 Tobias Kurth
A1 Andres Ingason
A1 George McMahon
A1 Lannie Ligthart
A1 Gisela M Terwindt
A1 Mikko Kallela
A1 Tobias M Freilinger
A1 Caroline Ran
A1 Scott G Gordon
A1 Anine H Stam
A1 Stacy Steinberg
A1 Guntram Borck
A1 Markku Koiranen
A1 Lydia Quaye
A1 Hieab HH Adams
A1 Terho Lehtimäki
A1 Antti-Pekka Sarin
A1 Juho Wedenoja
A1 David A Hinds
A1 Julie E Buring
A1 Markus Schürks
A1 Paul M Ridker
A1 Maria Gudlaug Hrafnsdottir
A1 Hreinn Stefansson
A1 Susan M Ring
A1 Jouke-Jan Hottenga
A1 Brenda WJH Penninx
A1 Markus Färkkilä
A1 Ville Artto
A1 Mari Kaunisto
A1 Salli Vepsäläinen
A1 Rainer Malik
A1 Andrew C Heath
A1 Pamela A F Madden
A1 Nicholas G Martin
A1 Grant W Montgomery
A1 Eija Hämäläinen
A1 Hailiang Huang
A1 Andrea E Byrnes
A1 Lude Franke
A1 Jie Huang
A1 Evie Stergiakouli
A1 Phil H Lee
A1 Cynthia Sandor
A1 Caleb Webber
A1 Zameel Cader
A1 Bertram Muller-Myhsok
A1 Stefan Schreiber
A1 Thomas Meitinger
A1 Johan G Eriksson
A1 Veikko Salomaa
A1 Kauko Heikkilä
A1 Elizabeth Loehrer
A1 Andre G Uitterlinden
A1 Albert Hofman
A1 Cornelia M van Duijn
A1 Lynn Cherkas
A1 Linda M. Pedersen
A1 Audun Stubhaug
A1 Christopher S Nielsen
A1 Minna Männikkö
A1 Evelin Mihailov
A1 Lili Milani
A1 Hartmut Göbel
A1 Ann-Louise Esserlind
A1 Anne Francke Christensen
A1 Thomas Folkmann Hansen
A1 Thomas Werge
A1 Jaakko Kaprio
A1 Arpo J Aromaa
A1 Olli Raitakari
A1 M Arfan Ikram
A1 Tim Spector
A1 Marjo-Riitta Järvelin
A1 Andres Metspalu
A1 Christian Kubisch
A1 David P Strachan
A1 Michel D Ferrari
A1 Andrea C Belin
A1 Martin Dichgans
A1 Maija Wessman
A1 Arn MJM van den Maagdenberg
A1 John-Anker Zwart
A1 Dorret I Boomsma
A1 George Davey Smith
A1 Kari Stefansson
A1 Nicholas Eriksson
A1 Mark J Daly
A1 Benjamin M Neale
A1 Jes Olesen
A1 Daniel I. Chasman
A1 Dale R Nyholt
A1 Aarno Palotie
A1 on behalf of the International Headache Genetics Consortium
YR 2015
UL http://biorxiv.org/content/early/2015/11/02/030288.abstract
AB Migraine is a debilitating neurological disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood. Some debate exists over whether migraine is a disease of vascular dysfunction, or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we performed the largest genetic study of migraine to date, comprising 59,674 cases and 316,078 controls from 22 GWA studies. We identified 45 independent single nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10−8) that map to 38 distinct genomic loci, including 28 loci not previously reported and the first locus identified on chromosome X. Furthermore, a subset analysis for migraine without aura (MO) identified seven of the same loci as from the full sample, whereas no loci reached genome-wide significance in the migraine with aura (MA) subset. In subsequent computational analyzes, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.