RT Journal Article
SR Electronic
T1 Reconstructing Genetic History of Siberian and Northeastern European Populations
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 029421
DO 10.1101/029421
A1 Emily HM Wong
A1 Andrey Khrunin
A1 Larissa Nichols
A1 Dmitry Pushkarev
A1 Denis Khokhrin
A1 Dmitry Verbenko
A1 Oleg Evgrafov
A1 James Knowles
A1 John Novembre
A1 Svetlana Limborska
A1 Anton Valouev
YR 2015
UL http://biorxiv.org/content/early/2015/10/18/029421.abstract
AB Siberia and Western Russia are home to over 40 culturally and linguistically diverse indigenous ethnic groups. Yet, genetic variation of peoples from this region is largely uncharacterized. We present whole-genome sequencing data from 28 individuals belonging to 14 distinct indigenous populations from that region. We combine these datasets with additional 32 modern-day and 15 ancient human genomes to build and compare autosomal, Y-DNA and mtDNA trees. Our results provide new links between modern and ancient inhabitants of Eurasia. Siberians share 38% of ancestry with descendants of the 45,000-year-old Ust’-Ishim people, who were previously believed to have no modern-day descendants. Western Siberians trace 57% of their ancestry to the Ancient North Eurasians, represented by the 24,000-year-old Siberian Mal’ta boy. In addition, Siberians admixtures are present in lineages represented by Eastern European hunter-gatherers from Samara, Karelia, Hungary and Sweden (from 8,000-6,600 years ago), as well as Yamnaya culture people (5,300-4,700 years ago) and modern-day northeastern Europeans. These results provide new evidence of ancient gene flow from Siberia into Europe.