RT Journal Article
SR Electronic
T1 Cell-cell interactions and evolution using evolutionary game theory
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 028746
DO 10.1101/028746
A1 David Basanta
YR 2015
UL http://biorxiv.org/content/early/2015/10/09/028746.abstract
AB Cancers arise from genetic abberations but also consistently display high levels of intra-tumor heterogeneity and evolve according to Darwinian dynamics. This makes evolutionary game theory an ideal tool in which to mathematically capture these cell-cell interactions and in which to investigate how they impact evolutionary dynamics. In this chapter we present some examples of how evolutionary game theory can elucidate cancer evolution.