TY - JOUR T1 - Hemodynamic response function in resting brain: disambiguating neural events and autonomic effects JF - bioRxiv DO - 10.1101/028514 SP - 028514 AU - Guo-Rong Wu AU - Daniele Marinazzo Y1 - 2015/01/01 UR - http://biorxiv.org/content/early/2015/10/06/028514.abstract N2 - It has been shown that resting state brain dynamics can be characterized by looking at sparse blood-oxygen-level dependent (BOLD) events, which can be retrieved by point process analysis. Cardiac activity can also induce changes in the BOLD signal, thus affect both the number of these events and the mapping between neural events and BOLD signal, namely the hemodynamic response. To isolate neural activity and autonomic effects, we compare the resting state hemodynamic response retrieved by means of a point process analysis with and without deconvolving the cardiac fluctuations. Brainstem and the surrounding cortical area (such as precuneus, insula etc.) are found to be significantly affected by cardiac pulses. Methodological and physiological implications are then discussed. ER -