PT - JOURNAL ARTICLE AU - Xuefang Zhao AU - Sarah B. Emery AU - Bridget Myers AU - Jeffrey M. Kidd AU - Ryan E. Mills TI - Resolving Complex Structural Genomic Rearrangements using a Randomized Approach AID - 10.1101/028217 DP - 2015 Jan 01 TA - bioRxiv PG - 028217 4099 - http://biorxiv.org/content/early/2015/10/04/028217.short 4100 - http://biorxiv.org/content/early/2015/10/04/028217.full AB - Complex chromosomal rearrangements consist of structural genomic alterations involving multiple instances of deletions, duplications, inversions, or translocations that co-occur either on the same chromosome or represent different overlapping events on homologous chromosomes. We present SVelter, an algorithm that first identifies regions of the genome suspected to harbor a complex event and then iteratively rearranges the local genome structure, in a randomized fashion, with each structure scored against characteristics of the observed sequencing data. We show that SVelter is able to accurately reconstruct these regions when compared to well-characterized genomes that have been deep sequenced with both short and long read technologies.