PT  - JOURNAL ARTICLE
AU  - Daniel Münch
AU  - C. Giovanni Galizia
TI  - DoOR 2.0 - Comprehensive Mapping of <em>Drosophila melanogaster</em> Odorant Responses
AID  - 10.1101/027920
DP  - 2015 Jan 01
TA  - bioRxiv
PG  - 027920
4099  - http://biorxiv.org/content/early/2015/09/30/027920.short
4100  - http://biorxiv.org/content/early/2015/09/30/027920.full
AB  - Odors elicit complex patterns of activated olfactory sensory neurons. Knowing the complete olfactome, i.e. responses in all sensory neurons for all odorants, is desirable to understand olfactory coding. The DoOR project combines all available Drosophila odorant response data into a single consensus response matrix. Since its first release many studies were published: receptors were deorphanized and several response profiles were expanded. In this study, we add to the odor-response profiles for four odorant receptors (Or10a, Or42b, Or47b, Or56a). We deorphanize Or69a, showing a broad response spectrum with the best ligands including 3-hydroxyhexanoate, alpha-terpineol, 3-octanol and linalool. We include these datasets into DoOR, and provide a comprehensive update of both code and data. The DoOR project has a web interface for quick queries (http://neuro.uni.kn/DoOR), and a downloadable, open source toolbox written in R, including all processed and original datasets. DoOR now gives reliable odorant-responses for nearly all Drosophila olfactory responding units, listing 693 odorants, for a total of 7381 data points.At the time of uploading this preprint, a preview of the DoOR 2.0 webpage is available at: http://neuro.uni.kn/DoOR/2.0