RT Journal Article
SR Electronic
T1 Integrated Genome Browser: visual analytics platform for genomics
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 026351
DO 10.1101/026351
A1 Nowlan H. Freese
A1 David C. Norris
A1 Ann E. Loraine
YR 2015
UL http://biorxiv.org/content/early/2015/09/15/026351.abstract
AB Motivation Genome browsers that support fast navigation through vast data sets and provide interactive visual analytics functions can help scientists achieve deeper insight into biological systems. Toward this end, we developed Integrated Genome Browser (IGB), a highly configurable, interactive and fast open source desktop genome browser.Results Here we describe multiple updates to IGB, including all-new capability to display and interact with data from high-throughput sequencing experiments. To demonstrate, we describe example visualizations and analyses of data sets from RNA-Seq, ChIP-Seq, and bisulfite sequencing experiments. Understanding results from genome-scale experiments requires viewing the data in the context of reference genome annotations and other related data sets. To facilitate this, we enhanced IGB’s ability to consume data from diverse sources, including Galaxy, Distributed Annotation, and IGB-specific Quickload servers. To support future visualization needs as new genome-scale assays enter wide use, we transformed the IGB codebase into a modular, extensible platform for developers to create and deploy all-new visualizations of genomic data.Availability IGB is open source and is freely available from http://bioviz.org/igb.Contact aloraine{at}uncc.edu