PT - JOURNAL ARTICLE AU - Tim Coulson AU - Sonya Clegg TI - Selection on heritable heterozygosity but no response to selection. Why? AID - 10.1101/026492 DP - 2015 Jan 01 TA - bioRxiv PG - 026492 4099 - http://biorxiv.org/content/early/2015/09/09/026492.short 4100 - http://biorxiv.org/content/early/2015/09/09/026492.full AB - The realisation that heterozygosity can be heritable has recently generated some elegant research. However, none of this work has discussed the fact that when heterozygote advantage occurs, heterozygosity can be heritable, yet allele frequencies remain at equilibrium and do not evolve with time. From a quantitative genetic perspective this means the character is heritable, is under selection, yet no response to selection is observed. We explain why this is the case, and discuss potential implications for the study of evolution in the wild.