RT Journal Article
SR Electronic
T1 The immunologic V-gene repertoire in mammals
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 002667
DO 10.1101/002667
A1 David Olivieri
A1 Bernardo von Haeften
A1 Christian Sánchez-Espinel
A1 Francisco Gambón-Deza
YR 2014
UL http://biorxiv.org/content/early/2014/02/13/002667.abstract
AB From recent whole genome shotgun data of 48 mammalian species, we have used our software VgenExtractor to obtain the functional V-gene sequence repertoire in order to conduct comparative phylogenetic studies. These studies reveal a large variation in the number of V-genes across mammalian species, ranging from a mere 36 V-genes in dolphins to nearly 600 V-genes in rats. Monotremes and marsupials are the only mammals possessing an additional locus, the TRMV, apart from the seven common loci found in mammals. Also, we show evidence for the loss of the light chain loci, specifically the Vκ chain in one microbat, and the Vλ chain in one rodent species. Finally, we suggest different features related to the evolution of immunoglobulin and T cell receptor loci, where frequent sequence duplications are seen in the former, while preserved and undiversified lineages are observed in the latter. All the V-gene sequences described in this study are available in the public database repository vgenerepertoire.org.