RT Journal Article
SR Electronic
T1 The LUX Score: A Metric for Lipidome Homology
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 013847
DO 10.1101/013847
A1 Chakravarthy Marella
A1 Andrew E Torda
A1 Dominik Schwudke
YR 2015
UL http://biorxiv.org/content/early/2015/08/19/013847.abstract
AB Motivation We propose a method for estimating lipidome homologies analogous to the ones used in sequence analysis and phylo-genetics.Results Algorithms were developed to quantify the structural similarity between lipids and to compute chemical space models of sets of lipid structures and lipidomes. When all lipid molecules of the LIPIDMAPS structure database were mapped in such a chemical space, they automatically formed clusters corresponding to conventional chemical families. Homologies between the lipidomes of four yeast strains based on our LUX score reflected the genetic relationship, although the score is based solely on lipid structures.Availability www.lux.fz-borstel.de